Faculté de médecine Faculté de médecine

Fedor Bezrukov

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Dr Fedor Bezrukov

Senior Bioinformatician and Physicist

A08.2525.a (CMU Building A – 8th floor)
+41 22 379 56 70
E-mail

My two main areas of expertise are bioinformatics and theoretical physics.

As a professor of theoretical physics at the University of Connecticut, US, and the University of Manchester, UK, I focused on inflationary cosmology, dark matter, neutrino physics, Beyond Standard Model (BSM) models, and numerical simulations in field theory.

Later, I shifted my interest and career to bioinformatics, which had long been a hobby of mine. I am currently leading in a range of bioinformatics projects related to the analysis of NGS data. This includes the analysis of whole-genome and exome DNA-Seq for human cancer genome studies; RNA-Seq and Ribo-Seq of mammals, yeast, and pathogenic bacteria to study transcription and translation processes; Hi-C analysis of chromatin structure; statistical analysis of gene expression and gene set enrichment analysis; as well as applications of machine learning.

Publications

Biology

  1. S. Kubik, I. Matyszczak, N. Toda, E. Magrinelli, P.-Y. Helleboid, E. Smith, F. Bezrukov, C. Ryder, J. Lopez, A. Harlé, and Z. Xu, 2024, “Critical assay parameters facilitating confident detection of expression changes, fusions and short variants in RNA isolated from tissue,” bioRxiv.
  2. F. Bezrukov, J. Prados, A. Renzoni, and O. O. Panasenko, 2021, “MazF toxin causes alterations in Staphylococcus aureus transcriptome, translatome and proteome that underlie bacterial dormancy,” Nucleic Acids Research, vol. 49, 2085
  3. G. Ramadori, R. M. Ioris, Z. Villanyi, R. Firnkes, O. O. Panasenko, G. Allen, G. Konstantinidou, E. Aras, X. Brenachot, T. Biscotti, A. Charollais, M. Luchetti, F. Bezrukov, A. Santinelli, M. Samad, P. Baldi, M. A. Collart, and R. Coppari, 2020, “FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth,” Cell Rep, vol. 30, 3851
  4. O. O. Panasenko, F. Bezrukov, O. Komarynets, and A. Renzoni, 2020, “YjbH Solubility Controls Spx in Staphylococcus aureus: Implication for MazEF Toxin-Antitoxin System Regulation,” Frontiers in Microbiology, vol. 11, 113
  5. Y. Liu et al., 2019, “Multi-omic measurements of heterogeneity in HeLa cells across laboratories,” Nat. Biotechnol., vol. 37, 314
  6. O. O. Panasenko, S. P. Somasekharan, Z. Villanyi, M. Zagatti, F. Bezrukov, R. Rashpa, J. Cornut, J. Iqbal, M. Longis, S. H. Carl, C. Peña, V. G. Panse, and M. A. Collart, 2019, “Co-translational assembly of proteasome subunits in NOT1-containing assemblysomes,” Nat. Struct. Mol. Biol., vol. 26, 110
  7. X. Bonilla et al., 2016, “Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma,” Nat Genet, vol. 48, 398

Physics

  1. F. Bezrukov and A. Keats, 2021, “Light inflaton model in a metastable Universe,” Phys. Rev. D, vol. 104, 075020
  2. F. Bezrukov and C. Shepherd, 2020, “A heatwave affair: mixed Higgs-R2 preheating on the lattice,” J. Cosmol. Astropart. Phys., vol. 2020, 028
  3. F. Bezrukov and A. Keats, 2020, “Heavy Light Inflaton and Dark Matter Production,” Phys. Rev. D, vol. 102, 115011
  4. M. Adams, F. Bezrukov, J. Elvin-Poole, J. J. Evans, P. Guzowski, B. Ó. Fearraigh, and S. Söldner-Rembold, 2020, “Direct comparison of sterile neutrino constraints from cosmological data, νe disappearance data and νμ→νe appearance data in a 3+1 model,” Eur. Phys. J. C, vol. 80, 758
  5. F. Bezrukov, S. Demidov, and D. Gorbunov, 2020, “No Miracle in Gravity Portals,” arXiv:2006.03431
  6. F. Bezrukov, A. Chudaykin, and D. Gorbunov, 2020, “Scalar induced resonant sterile neutrino production in the early Universe,” Phys. Rev. D, vol. 101, 103516
  7. F. Bezrukov, A. Chudaykin, and D. Gorbunov, 2019, “Induced resonance makes light sterile neutrino Dark Matter cool,” Phys. Rev. D, vol. 99, 083507
  8. F. Bezrukov, D. Gorbunov, C. Shepherd, and A. Tokareva, 2019, “Some like it hot: R2 heals Higgs inflation, but does not cool it,” Phys. Lett. B, vol. 795, 657
  9. F. Bezrukov, D. Gorbunov, and I. Timiryasov, 2018, “Uncertainties of hadronic scalar decay calculations,” arXiv:1812.08088 [hep-ph]
  10. A. Belyaev, F. Bezrukov, C. Shepherd, and D. Ross, 2018, “Problems with Higgsplosion,” Phys. Rev. D, vol. 98, 113001
  11. F. Bezrukov, M. Pauly, and J. Rubio, 2018, “On the robustness of the primordial power spectrum in renormalized Higgs inflation,” JCAP, vol. 1802, 040
  12. R. Adhikari et al., 2017, “A White Paper on keV Sterile Neutrino Dark Matter,” J. Cosmol. Astropart. Phys., vol. 2017, 025
  13. F. Bezrukov, A. Chudaykin, and D. Gorbunov, 2017, “Hiding an elephant: heavy sterile neutrino with large mixing angle does not contradict cosmology,” JCAP, vol. 1706, 051
  14. F. Bezrukov and D. Gorbunov, 2016, “On the applicability of approximations used in calculation of spectrum of Dark Matter particles produced in particle decays,” Phys. Rev. D, vol. 93, 063502
  15. S. Alekhin, W. Altmannshofer, T. Asaka, B. Batell, F. Bezrukov, and others, 2016, “A facility to search for hidden particles at the CERN SPS: the SHiP physics case”.Rep. Prog. Phys., vol. 79, 124201
  16. F. Bezrukov, D. Levkov, and S. Sibiryakov, 2015, “Semiclassical S-matrix for black holes,” J. High Energ. Phys., vol. 2015, 1
  17. F. Bezrukov and M. Shaposhnikov, 2015, “Why should we care about the top quark Yukawa coupling?,” J.Exp.Theor.Phys., vol. 120, 335
  18. F. Bezrukov, J. Rubio, and M. Shaposhnikov, 2015, “Living beyond the edge: Higgs inflation and vacuum metastability,” Phys. Rev., vol. D92, 083512
  19. F. Bezrukov and M. Shaposhnikov, 2014, “Higgs inflation at the critical point,” Phys. Lett., vol. B734, 249
  20. F. Bezrukov and D. Gorbunov, 2014, “Relic Gravity Waves and 7 keV Dark Matter from a GeV scale inflaton,” Phys.Lett., vol. B736, 494
  21. F. Bezrukov, 2013, “The Planck and LHC results and particle physics,” arXiv: arXiv:1312.4100
  22. F. Bezrukov, G. K. Karananas, J. Rubio, and M. Shaposhnikov, 2013, “Higgs-Dilaton Cosmology: an effective field theory approach,” Phys.Rev., vol. D87, 096001
  23. F. Bezrukov, 2013, “The Higgs field as an inflaton,” Class.Quant.Grav., vol. 30, 214001
  24. F. Bezrukov, A. Kartavtsev, and M. Lindner, 2013, “Leptogenesis in models with keV sterile neutrino dark matter,” J.Phys., vol. G40, 095202
  25. F. Bezrukov and D. Gorbunov, 2013, “Light inflaton after LHC8 and WMAP9 results,” Journal of High Energy Physics, vol. 07, 140
  26. K. N. Abazajian et al., 2012, “Light Sterile Neutrinos: A White Paper,” arXiv:1204.5379.
  27. F. Bezrukov and H. M. Lee, 2012, “Model dependence of the bremsstrahlung effects from the superluminal neutrino at OPERA,” Phys. Rev. D, vol. 85, 031901
  28. F. Bezrukov, M. Kalmykov, B. Kniehl, and M. Shaposhnikov, 2012, “Higgs Boson Mass and New Physics,” JHEP, vol. 1210, 140
  29. F. Bezrukov, P. Channuie, J. J. Joergensen, and F. Sannino, 2012, “Composite Inflation Setup and Glueball Inflation,” Phys.Rev., vol. D86, 063513
  30. L. Alberte and F. Bezrukov, 2012, “Semiclassical Calculation of Multiparticle Scattering Cross Sections in Classicalizing Theories,” Phys.Rev., vol. D86, 105008
  31. F. Bezrukov and D. Gorbunov, 2012, “Distinguishing between R2-inflation and Higgs-inflation,” Phys. Lett., vol. B713, 365
  32. F. Bezrukov, F. Kahlhoefer, and M. Lindner, 2011, “Interplay between scintillation and ionization in liquid xenon Dark Matter searches,” Astroparticle Physics, vol. 35, 119
  33. F. Bezrukov, A. Magnin, M. Shaposhnikov, and S. Sibiryakov, 2011, “Higgs inflation: consistency and generalisations,” JHEP, vol. 1101, 016
  34. F. Bezrukov, D. Gorbunov, and M. Shaposhnikov, 2011, “Late and early time phenomenology of Higgs-dependent cutoff,” JCAP, vol. 1110, 001
  35. F. Bezrukov, H. Hettmansperger, and M. Lindner, 2010, “keV sterile neutrino Dark Matter in gauge extensions of the Standard Model,” Phys. Rev., vol. D81, 085032
  36. F. Bezrukov and D. Gorbunov, 2010, “Light inflaton Hunter’s Guide,” JHEP, vol. 05, 010
  37. F. Bezrukov, 2010, “Inflation in the standard model and νMSM with non-minimal coupling to gravity,” AIP Conf.Proc., vol. 1241, 511
  38. F. L. Bezrukov, A. Magnin, and M. Shaposhnikov, 2009, “Standard Model Higgs boson mass from inflation,” Phys. Lett., vol. B675, 88
  39. F. L. Bezrukov and Y. Burnier, 2009, “Towards a solution of the strong CP problem by compact extra dimensions,” Phys.Rev., vol. D80, 125004
  40. F. Bezrukov and M. Shaposhnikov, 2009, “Standard Model Higgs boson mass from inflation: two loop analysis,” JHEP, vol. 07, 089
  41. F. Bezrukov, D. Gorbunov, and M. Shaposhnikov, 2009, “On initial conditions for the Hot Big Bang,” JCAP, vol. 0906, 029
  42. A. Anisimov, Y. Bartocci, and F. L. Bezrukov, 2009, “Inflaton mass in the νMSM inflation,” Phys. Lett., vol. B671, 211
  43. F. Bezrukov and M. Shaposhnikov, 2008, “The Standard Model Higgs boson as the inflaton,” Phys. Lett., vol. B659, 703
  44. F. L. Bezrukov, 2008, “Non-minimal coupling in inflation and inflating with the Higgs boson,” in Proceedings, 15th International Seminar on High Energy Physics (Quarks 2008)
  45. F. Bezrukov, 2008, “νMSM and its experimental tests,” J. Phys. Conf. Ser., vol. 110, 082002
  46. F. L. Bezrukov and M. Shaposhnikov, 2007, “Searching for dark matter sterile neutrino in laboratory,” Phys. Rev., vol. D75, 053005
  47. F. Bezrukov, Y. Burnier, and M. Shaposhnikov, 2006, “Can an odd number of fermions be created due to chiral anomaly?,” Phys. Rev., vol. D73, 045008
  48. F. Bezrukov, 2005, “νMSM predictions for neutrinoless double beta decay,” Phys. Rev., vol. D72, 071303
  49. F. Bezrukov and D. Levkov, 2004, “The θ instantons in the SU(2) Higgs theory,” Theor. Math. Phys., vol. 138, 397
  50. F. L. Bezrukov and D. Levkov, 2004, “Dynamical tunneling of bound systems through a potential barrier: complex way to the top,” J. Exp. Theor. Phys., vol. 98, 820
  51. F. L. Bezrukov, D. Levkov, C. Rebbi, V. A. Rubakov, and P. Tinyakov, 2003, “Suppression of baryon number violation in electroweak collisions: Numerical results,” Phys. Lett., vol. B574, 75
  52. F. L. Bezrukov, D. Levkov, C. Rebbi, V. A. Rubakov, and P. Tinyakov, 2003, “Semiclassical study of baryon and lepton number violation in high-energy electroweak collisions,” Phys. Rev., vol. D68, 036005
  53. F. Bezrukov and D. Levkov, 2003, “Transmission through a potential barrier in quantum mechanics of multiple degrees of freedom: complex way to the top,” arXiv:quant-ph/0301022
  54. F. L. Bezrukov, D. S. Gorbunov, and Yu. G. Kudenko, 2003, “Transverse muon polarization in K+→μ+νμγ: Scanning over the Dalitz plot,” Eur. Phys. J., vol. C30, 487
  55. F. L. Bezrukov, D. S. Gorbunov, and Yu. G. Kudenko, 2003, “Pinning down the kaon form factors in K+→μ+νμγ decay,” Phys. Rev., vol. D67, 091503
  56. F. Bezrukov and D. Gorbunov, 2002, “T-odd Correlations in π→eνeγ Decay,” arXiv:hep-ph/0205338.
  57. F. L. Bezrukov and D. S. Gorbunov, 2002, “T-odd correlations in π→eνeγ and π→μνμγ decays,” Phys. Rev., vol. D66, 054012, 
  58. F. Bezrukov, C. Rebbi, V. Rubakov, and P. Tinyakov, 2001, “Instanton-like processes in particle collisions: A numerical study of the SU(2)-Higgs theory below the sphaleron energy,” in Proc.XI-th Int.School “Particles and Cosmology”
  59. F. L. Bezrukov, 1998, “Using singular classical solutions for calculating multiparticle cross sections in field theory,” Theor. Math. Phys., vol. 115, 647
  60. F. L. Bezrukov, M. V. Libanov, and S. V. Troitsky, 1997, “Singular classical solutions and tree multiparticle cross-sections,” Surveys High Energ. Phys., vol. 10, 395
  61. F. L. Bezrukov, M. V. Libanov, and S. V. Troitsky, 1995, “O(4) symmetric singular solutions and multiparticle cross-sections in ϕ4 theory at tree level,” Mod. Phys. Lett., vol. A10, 2135
  62. F. L. Bezrukov, M. V. Libanov, D. T. Son, and S. V. Troitsky, 1995, “Singular Classical Solutions and Tree Multiparticle Cross Sections in Scalar Theories,” in Proc.of X Int.Workshop on High Energy Physics and Quantum Field Theory

Team