Synaptic circuits in AD

Neurodegenerative diseases (NDDs) are progressive and fatal disorders characterized by selective neuronal loss in specific brain regions. Among them, Alzheimer’s disease (AD) is the most prevalent. A distinctive hallmark of AD is its spatio-temporal propagation through interconnected brain regions, following functional neural circuits.

Our project aims to explore the mechanisms of AD propagation across different regions of the human brain, using post-mortem samples from the Geneva Brain Bank (GBB). While previous studies have mostly relied on preclinical models, our work focuses on human tissues, providing unique insights into the regional and cellular features associated with the spreading of AD pathology.

Methods : histology, expansion microscopy, RNA-seq, transcriptomic analysis