Gut brain axis in psychiatric and metabolic disorders

Growing evidence implicates dysfunction of the enteric nervous system in a wide range of psychiatric, metabolic, and gastrointestinal disorders, including irritable bowel syndrome, inflammatory bowel disease, and neurodegenerative conditions. Despite its recognized importance, the cellular heterogeneity, spatial architecture, and signaling dynamics of the human enteric nervous system remain largely uncharacterized.

 

This project aims to provide new insights into the three-dimensional structural and molecular organization of the enteric nervous system, capturing its anatomical and functional complexity. By examining gut alterations under pathological conditions, we seek to elucidate the mechanisms underlying enteric nervous system-associated disorders and to identify potential applications for improved clinical diagnostics and targeted therapeutic strategies.