Circulating factors that regulate energy balance

Obesity and its associated disorders, such as type 2 diabetes and fatty liver disease, are a major public health problem. As obesity results from an imbalance between energy intake and expenditure, a better understanding of the circulating factors secreted by the liver to control energy balance may provide new therapeutic approaches.

Researchers from Prof. Michelangelo Foti’s laboratory have discovered that a deficiency of the PTEN protein alters the secretion by the liver of several factors involved in the regulation of energy balance. These circulating factors could represent potential therapeutic targets to treat obesity and its associated disorders.


To learn more about the role of PTEN in energy metabolism and obesity-related disorders, download their publication in the International Journal of Molecular Sciences.



28 Apr 2022