The impact of obesity, insulin resistance, and diabetes on renal metabolism
Around 403.000 patients per year are diagnosed with renal carcinomas worldwide. Renal carcinomas are promoted by several factors such as obesity/diabetes, chronic kidney disease, smoking, toxin exposure, genetic predispositions and high blood pressure.
This diverse array of risk factors leads to very strong differences in terms of tumour morphology, mutational profile and metabolic status and testifies to the need to deepen our understanding of the pathological processes involved in this disease to develop novel therapeutic approaches to fight renal cancer.
Dr Gjorgjieva’s research aims, therefore, at deciphering the different molecular mechanisms involved in the incidence and progression of renal cancer.
She is working on the development of an in vivo model of renal carcinoma that better mimics the pathology observed in humans and might open new therapeutic avenues.
SELECTED PUBLICATIONS
- Correia De Sousa M, Arnoux G, Yvon R, Maeder Garavaglia C, Fournier M, Morin N, Dolicka DD, Delangre E, Tuerkal M, Charlemagne T, De Seigneux Matthey S, Legouis D, Maechler P, Feraille E, Foti M, Gjorgjieva Ducros M. ERMP1 as a newly identified ER stress gatekeeper in chronic kidney disease. American journal of physiology. Renal physiology. 2025;328(3):F375–88.
- Gjorgjieva Ducros M, Calo NV, Sobolewski C, Portius D, Pitetti J-L, Berthou F, Ay Berthomieu A-S, Peyrou M, Bourgoin L, Maeder Garavaglia C, Fournier M, Correia De Sousa M, Delangre E, Vinet L, Montet XCR, Sempoux C, Nef S, Foti M. Hepatic IR and IGF1R signaling govern distinct metabolic and carcinogenic processes upon PTEN deficiency in the liver. JHEP reports. 2025;7(4):101305.
- Gjorgjieva Ducros M, Ay Berthomieu A-S, Correia De Sousa M, Delangre E, Dolicka DD, Sobolewski C, Maeder Garavaglia C, Fournier M, Sempoux C, Foti M. MiR-22 deficiency fosters hepatocellular carcinoma development in fatty liver. Cells. 2022;11(18):2860.
- Gjorgjieva M, Sobolewski C, Ay Berthomieu A-S, Abegg D, Correia De Sousa M, Portius D, Berthou F, Fournier M, Maeder Garavaglia C, Rantakari P, Zhang F-P, Poutanen M, Picard D, Montet XCR, Nef S, Adibekian A, Foti M. Genetic ablation of MiR-22 fosters diet-induced obesity and NAFLD development. Journal of Personalized Medicine. 2020;10(4):E170.
- Gjorgjieva M, Sobolewski C, Dolicka DD, Correia De Sousa M, Foti M. miRNAs and NAFLD: from pathophysiology to therapy. Gut. 2019;68(11):2065–79.