Current Selection : 7 Research Groups
We are mainly interested in synthesizing topologically complex molecules, using the hydrophobic effect as a driving force. Molecules with complex topologies are entangled macrocycles composed of one or many components, named knots and links, respectively. The formation of knots and links represent an original, but efficient, way to control the three–dimensional shape of molecules, making these structures ideal candidates for a variety of biological applications, such as sequence- and structure-specific binding to proteins and DNA. However, they remain extremely difficult to produce using the current methods of chemistry, and their potential applications constitute an entirely unexplored field.
Molecular tools to study and pertub Hedgehog signaling and the primary cilium
Synthetic organic chemistry, chirality and molecular recognition: Organometallic reactivity and asymmetric transformations; Synthetic, physical and biological applications of highly stable (chiral) carbenium ions; NMR enantiodifferentiation of chiral substances; Hexacoordinated phosphorus chemistry
Organic Synthesis, Supramolecular Chemistry, Bioorganic Chemistry, Functional Systems, Unorthodox Interactions
Synthetic chemistry, asymmetric catalysis, reaction mechanism, characterization of reactive intermediates
The focus of our group is to reach an in-depth theoretical understanding of regio- and enantion-selective processes.