Current Selection : 7 Research Groups
We are a chemical biology group and our research goal is to discover novel signaling and metabolic pathways by using the strategy of forward chemical genetics. We are particularly interested in enzymes involved in cancer and autoimmune diseases. To achieve our goals, we apply a broad repertoire of different technologies ranging from synthetic chemistry to cell biology and mass spectrometry-based proteomics and metabolomics.
We are mainly interested in synthesizing topologically complex molecules, using the hydrophobic effect as a driving force. Molecules with complex topologies are entangled macrocycles composed of one or many components, named knots and links, respectively. The formation of knots and links represent an original, but efficient, way to control the three–dimensional shape of molecules, making these structures ideal candidates for a variety of biological applications, such as sequence- and structure-specific binding to proteins and DNA. However, they remain extremely difficult to produce using the current methods of chemistry, and their potential applications constitute an entirely unexplored field.
Methodology and signal processing in Nuclear Magnetic Resonance; elucidation of structures of natural products
Synthetic organic chemistry, chirality and molecular recognition: Organometallic reactivity and asymmetric transformations; Synthetic, physical and biological applications of highly stable (chiral) carbenium ions; NMR enantiodifferentiation of chiral substances; Hexacoordinated phosphorus chemistry
Organic Synthesis, Supramolecular Chemistry, Bioorganic Chemistry, Functional Systems, Unorthodox Interactions
Synthetic chemistry, asymmetric catalysis, reaction mechanism, characterization of reactive intermediates