Marcos Gonzalez-Gaitan



  • López-Andarias, Javier; Saarbach, Jacques; Moreau, Dimitri; Cheng, Yangyang; Derivery, Emmanuel; Laurent, Quentin; González-Gaitán, Marcos; Winssinger, Nicolas; Sakai, Naomi; Matile, Stefan (2020) Cell-Penetrating Streptavidin:  A General Tool for Bifunctional Delivery with Spatiotemporal Control, Mediated by Transport Systems such as Adaptive Benzopolysulfane Networks. J. Am. Chem. Soc. 142 (10) 4784-4792.


  • Aguilar-Hidalgo, Daniel; Hadjivasilou, Zena; Romanova-Michaelides, Maria; Gonzalez-Gaitan, Marcos; Juelicher, Frank (2019) Dynamic modes of morphogen transport., e-Print Archive, Physics. [accepted]
  • Bartolami, Eline; Basagiannis, Dimitris; Zong, Lili; Martinent, Rémi; Okamoto, Yasunori; Laurent, Quentin; Ward, Thomas R.; Gonzalez-Gaitan, Marcos; Sakai, Naomi; Matile, Stefan (2019) Diselenolane-Mediated Cellular Uptake:  Efficient Cytosolic Delivery of Probes, Peptides, Proteins, Artificial Metalloenzymes and Protein-Coated Quantum Dots. Chem. Eur. J. 25 (16) 4047-4051.



  • Derivery, Emmanuel; Bartolami, Eline; Matile, Stefan; Gonzalez-Gaitan, Marcos (2017) Efficient Delivery of Quantum Dots into the Cytosol of Cells Using Cell-Penetrating Poly(disulfide)s. J. Am. Chem. Soc. 139 (30) 10172-10175.
  • Loubéry, Sylvain; Daeden, Alicia; Seum, Carole; Holtzer, Laurent; Moraleda, Ana; Damond, Nicolas; Derivery, Emmanuel; Schmidt, Thomas; Gonzalez-Gaitan, Marcos (2017) Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division. Nat. Commun. 8 15285.
  • Spannl, Stephanie; Kumichel, Alexandra; Hebbar, Sarita; Kapp, Katja; Gonzalez-Gaitan, Marcos; Winkler, Sylke; Blawid, Rosana; Jessberger, Gregor; Knust, Elisabeth (2017) The Crumbs_C isoform of Drosophila shows tissue- and stage-specific expression and prevents light-dependent retinal degeneration. Biol. Open 6 (2) 165-175.


  • Soleimanpour, Saeideh; Colom, Adai; Derivery, Emmanuel; Gonzalez-Gaitan, Marcos; Roux, Aurelien; Sakai, Naomi; Matile, Stefan (2016) Headgroup Engineering in Mechanosensitive Membrane Probes. Chem. Commun. 52 (100) 14450-14453.
  • Holtzer, Laurent; Oleinich, Igor; Anzola, Marcello; Lindberg, Eric; Sadhu, Kalyan K.; Gonzalez-Gaitan, Marcos; Winssinger, Nicolas (2016) Nucleic Acid Templated Chemical Reaction in a Live Vertebrate. ACS Cent. Sci. 2 (6) 394-400.
  • Mamińska1, Agnieszka; Bartosik, Anna; Banach-Orłowska, Magdalena; Pilecka, Iwona; Jastrzębski, Kamil; Zdżalik-Bielecka, Daria; Castanon, Irinka; Poulain, Morgane; Neyen, Claudine; Wolińska-Nizioł, Lidia; Toruń, Anna; Szymańska, Ewelina; Kowalczyk, Agata; Piwocka, Katarzyna; Simonsen, Anne; Stenmark, Harald; Fürthauer, Maximilian; González-Gaitán, Marcos; Miaczynska, Marta (2016) ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors. Sci. Signaling 9 (411) ra8.


  • Derivery, Emmanuel; Seum, Carole; Daeden, Alicia; Loubéry, Sylvain; Holtzer, Laurent; Jülicher, Frank; Gonzalez-Gaitan, Marcos (2015) Polarized endosome dynamics by spindle asymmetry during asymmetric cell division. Nature 528 (7581) 280-285.
  • Lukinavičius, Gražvydas; Blaukopf, Claudia; Pershagen, Elias; Schena, Alberto; Reymond, Luc; Derivery, Emmanuel; Gonzalez-Gaitan, Marcos; D’Este, Elisa; Hell, Stefan W.; Wolfram Gerlich, Daniel; Johnsson, Kai (2015) SiR–Hoechst is a far-red DNA stain for live-cell nanoscopy. Nat. Commun. 6 8497.
  • Gonzalez-Gaitan, Marcos; Roux, Aurélien (2015) When cell biology meets theory. J. Cell Biol. 210 (7) 1041-1045.
  • Toruń, Anna; Szymańska, Ewelina; Castanon, Irinka; Wolińska-Nizioł, Lidia; Bartosik, Anna; Jastrzębski, Kamil; Miętkowska, Magdalena; González-Gaitán, Marcos; Miaczynska, Marta; Königshoff, Melanie (2015) Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling. PLoS ONE 10 (6) e0130818.
  • Romanova-Michaelides, Maria; Aguilar-Hidalgo, Daniel; Jülicher, Frank; Gonzalez-Gaitan, Marcos (2015) The wing and the eye: a parsimonious theory for scaling and growth control?. Wiley Interdiscip. Rev.: Dev. Biol. 4 (6) 591-608.
  • Loubéry, Sylvain; Seum, Carole; Moraleda, Ana; Daeden, Alicia; Fürthauer, Maximilian; Gonzalez-Gaitan, Marcos (2015) [Erratum] Uninflatable and Notch Control the Targeting of Sara Endosomes during Asymmetric Division. Curr. Biol. 25 (6) 817-818.
  • Kressmann, Sabine; Campos, Claudia; Castanon, Irinka; Fürthauer, Maximilian; González-Gaitán, Marcos (2015) Directional Notch trafficking in Sara endosomes during asymmetric cell division in the spinal cord. Nat. Cell Biol. 17 (3) 333-339.
  • Dal Molin, Marta; Verolet, Quentin; Colom, Adai; Letrun, Romain; Derivery, Emmanuel; Gonzalez-Gaitan, Marcos; Vauthey, Eric; Roux, Aurélien; Sakai, Naomi; Matile, Stefan (2015) Fluorescent Flippers for Mechanosensitive Membrane Probes. J. Am. Chem. Soc. 137 (2) 568-571.



  • Kicheva, Anna; Holtzer, Laurent; Wartlick, Ortrud; Schmidt, Thomas; González-Gaitán, Marcos (2013) Quantitative Imaging of Morphogen Gradients in Drosophila Imaginal Discs. Cold Spring Harbor Protoc. 2013 (5) 387-403.
  • Guan, Xue Li; Cestra, Gianluca; Shui, Guanghou; Kuhrs, Antje; Schittenhelm, Ralf B.; Hafen, Ernst; van der Goot, F. Gisou; Robinett, Carmen C.; Gatti, Maurizio; Gonzalez-Gaitan, Marcos; Wenk, Markus R. (2013) Biochemical Membrane Lipidomics during Drosophila Development. Dev. Cell 24 (1) 98-111.
  • Castanon, Irinka; Abrami, Laurence; Holtzer, Laurent; Heisenberg, Carl-Philipp; van der Goot, F. Gisou; González-Gaitán, Marcos (2013) Anthrax toxin receptor 2a controls mitotic spindle positioning. Nat. Cell Biol. 15 (1) 28-39.


  • Kicheva, Anna; Bollenbach, Tobias; Wartlick, Ortrud; Jülicher, Frank; Gonzalez-Gaitan, Marcos (2012) Investigating the principles of morphogen gradient formation: from tissues to cells. Curr. Opin. Genet. Dev. 22 (6) 527-532.
  • Kobayashi, Tomonori; Komatsu, Toru; Kamiya, Mako; Campos, Cláudia; González-Gaitán, Marcos; Terai, Takuya; Hanaoka, Kenjiro; Nagano, Tetsuo; Urano, Yasuteru (2012) Highly Activatable and Environment-Insensitive Optical Highlighters for Selective Spatiotemporal Imaging of Target Proteins. J. Am. Chem. Soc. 134 (27) 11153-11160.
  • Wartlick, Ortrud; Mumcu, Peer; Julicher, Frank; Gonzalez-Gaitan, Marcos (2012) Response to Comment on “Dynamics of Dpp Signaling and Proliferation Control”. Science 335 (6067) 401.


  • Castanon, Irinka; González-Gaitán, Marcos (2011) Integrating levels of complexity: a trend in developmental biology. Curr. Opin. Cell Biol. 23 (6) 647-649.
  • Castanon, Irinka; González-Gaitán, Marcos (2011) Oriented cell division in vertebrate embryogenesis. Curr. Opin. Cell Biol. 23 (6) 697-704.
  • Wartlick, Ortrud; González-Gaitán, Marcos (2011) The missing link: implementation of morphogenetic growth control on the cellular and molecular level. Curr. Opin. Genet. Dev. 21 (6) 690-695.
  • Wartlick, Ortrud; Mumcu, Peer; Jülicher, Frank; Gonzalez-Gaitan, Marcos (2011) Understanding morphogenetic growth control – lessons from flies. Nat. Rev. Mol. Cell Biol. 12 (9) 594-604.
  • Semrau, Stefan; Holtzer, Laurent; González-Gaitán, Marcos; Schmidt, Thomas (2011) Quantification of Biological Interactions with Particle Image Cross-Correlation Spectroscopy (PICCS). Biophys. J. 100 (7) 1810-1818.
  • Wartlick, Ortrud; Mumcu, P.; Kicheva, Anna; Bittig, T.; Seum, Carole; Julicher, Frank; Gonzalez-Gaitan, Marcos (2011) Dynamics of Dpp Signaling and Proliferation Control. Science 331 (6021) 1154-1159.
  • Campos, Cláudia; Kamiya, Mako; Banala, Sambashiva; Johnsson, Kai; González-Gaitán, Marcos (2011) Labelling cell structures and tracking cell lineage in zebrafish using SNAP-tag. Dev. Dyn. 240 (4) 820-827.


  • Assaker, Gloria; Ramel, Damien; Wculek, Stefanie K.; Gonzalez-Gaitan, Marcos; Emery, Gregory (2010) Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration. Proc. Natl. Acad. Sci. U. S. A. 107 (52) 22558-22563.
  • Mottola, Giovanna; Classen, Anne-Kathrin; Gonzalez-Gaitan, Marcos; Eaton, Suzanne; Zerial, Marino (2010) A novel function for the Rab5 effector Rabenosyn-5 in planar cell polarity. Development 137 (14) 2353-2364.


  • González-Gaitán, Marcos; Gruenberg, Jean; Halazonetis, Thanos; Laemmli, Ulrich K.; Matter, Jean-Marc; Riezman, Howard; Schaad, Olivier; Soldati, Thierry; Watanabe, Reika (2009) The Biochemistry Department of the University of Geneva: Understanding the Molecular Basis and Function of Intracellular Organization. CHIMIA 63 (12) 830-834.
  • Fürthauer, Maximilian; González-Gaitán, Marcos (2009) Endocytosis and mitosis: A two-way relationship. Cell Cycle 8 (20) 3311-3318.
  • Bittig, T.; Wartlick, Ortrud; González-Gaitán, Marcos; Jülicher, Frank (2009) Quantification of growth asymmetries in developing epithelia. Eur. Phys. J. E 30 (1) 93-99.
  • Wartlick, Ortrud; Kicheva, Anna; Gonzalez-Gaitan, Marcos (2009) Morphogen Gradient Formation. Cold Spring Harbor Perspect. Biol. 1 (3) a001255-a001255.
  • Oates, Andrew C.; Gorfinkiel, Nicole; González-Gaitán, Marcos; Heisenberg, Carl-Philipp (2009) Quantitative approaches in developmental biology. Nat. Rev. Genet. 10 (8) 517-530.
  • Fürthauer, Maximilian; González-Gaitán, Marcos (2009) Tales of 1001 Functions: The Multiple Roles of Membrane Trafficking in Development. Traffic 10 (7) 781-782.
  • Fürthauer, Maximilian; González-Gaitán, Marcos (2009) Endocytosis, asymmetric cell division, stem cells and cancer: Unus pro omnibus, omnes pro uno. Mol. Oncol. 3 (4) 339-353.
  • Fürthauer, Maximilian; González-Gaitán, Marcos (2009) Endocytic Regulation of Notch Signalling During Development. Traffic 10 (7) 792-802.
  • Coumailleau, Franck; Fürthauer, Maximilian; Knoblich, J. A.; González-Gaitán, Marcos (2009) Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division. Nature 458 (7241) 1051-1055.
  • Peralta, Susana; Gómez, Yolanda; González-Gaitán, Marcos A.; Moya, Fernando; Vinós, Javier (2009) Notch down-regulation by endocytosis is essential for pigment cell determination and survival in the Drosophila retina. Mech. Dev. 126 (3-4) 256-269.



  • Dyer, Naomi; Rebollo, Elena; Dominguez, Paloma; Elkhatib, Nadia; Chavrier, Philippe; Daviet, Laurent; Gonzalez, Cayetano; Gonzalez-Gaitan, Marcos (2007) Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes. Development 134 (24) 4437-4447.
  • Pantazis, Periklis; González-Gaitán, Marcos (2007) Localized multiphoton photoactivation of paGFP in Drosophila wing imaginal discs. J. Biomed. Opt. 12 (4) 044004.
  • Kicheva, Anna; Pantazis, Periklis; Bollenbach, Tobias; Kalaidzidis, Yannis; Bittig, Thomas; Julicher, Frank; Gonzalez-Gaitan, Marcos (2007) Kinetics of Morphogen Gradient Formation. Science 315 (5811) 521-525.
  • Bollenbach, Tobias; Kruse, K.; Pantazis, Periklis; González-Gaitán, Marcos; Jülicher, Frank (2007) Morphogen transport in epithelia. Phys. Rev. E 75 (1) 011901.


  • Bökel, Christian; Schwabedissen, Anja; Entchev, Eugeni; Renaud, Olivier; Gonzalez-Gaitan, Marcos (2006) Sara Endosomes and the Maintenance of Dpp Signaling Levels Across Mitosis. Science 314 (5802) 1135-1139.
  • Dudu, Veronica; Bittig, Thomas; Entchev, Eugeni; Kicheva, Anna; Jülicher, Frank; González-Gaitán, Marcos (2006) Erratum: Postsynaptic Mad Signaling at the Drosophila Neuromuscular Junction. Curr. Biol. 16 (12) 1256.
  • Dudu, Veronica; Bittig, Thomas; Entchev, Eugeni; Kicheva, Anna; Jülicher, Frank; González-Gaitán, Marcos (2006) Postsynaptic Mad Signaling at the Drosophila Neuromuscular Junction. Curr. Biol. 16 (7) 625-635.


  • Winkler, Sylke; Schwabedissen, Anja; Backasch, Dana; Bökel, Christian; Seidel, Claudia; Bönisch, Stefanie; Fürthauer, Maximilian; Kuhrs, Antje; Cobreros, Laura; Brand, Michael; González-Gaitán, Marcos (2005) Target-selected mutant screen by TILLING in Drosophila. Genome Res. 15 (5) 718-723.
  • Bollenbach, T.; Kruse, K.; Pantazis, P.; González-Gaitán, Marcos; Jülicher, F. (2005) Robust Formation of Morphogen Gradients. Phys. Rev. Lett. 3 (1) 01813.


  • Williams, P. Huw; Hagemann, Anja; González-Gaitán, Marcos; Smith, James C. (2004) Erratum: Visualizing Long-Range Movement of the Morphogen Xnr2 in the Xenopus Embryo. Curr. Biol. 14 (24) 2312.
  • Williams, P. Huw; Hagemann, Anja; González-Gaitán, Marcos; Smith, James C. (2004) Visualizing Long-Range Movement of the Morphogen Xnr2 in the Xenopus Embryo. Curr. Biol. 14 (21) 1916-1923.
  • Kruse, Karsten (2004) Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model. Development 131 (19) 4843-4856.
  • Dudu, Veronica; Pantazis, Periklis; González-Gaitán, Marcos (2004) Membrane traffic during embryonic development: epithelial formation, cell fate decisions and differentiation. Curr. Opin. Cell Biol. 16 (4) 407-414.



  • Berdnik, Daniela; Török, Tibor; González-Gaitán, Marcos; Knoblich, Juergen A. (2002) The Endocytic Protein α-Adaptin Is Required for Numb-Mediated Asymmetric Cell Division in Drosophila. Developmental Cell 3 (2) 221-231.
  • Guichet, Antoine; Wucherpfennig, Tanja; Dudu, Veronica; Etter, Sylvain; Wilsch‐Bräuniger, Michaela; Hellwig, Andrea; González‐Gaitán, Marcos; Huttner, Wieland B.; Schmidt, Anne A. (2002) Essential role of endophilin A in synaptic vesicle budding at the Drosophila neuromuscular junction. EMBO J. 21 (7) 1661-1672.
  • Entchev, Eugeni V.; González-Gaitán, Marcos A. (2002) Morphogen Gradient Formation and Vesicular Trafficking. Traffic 3 (2) 98-109.


  • Entchev, Eugeni V.; Schwabedissen, Anja; González-Gaitán, Marcos (2000) Gradient Formation of the TGF-β Homolog Dpp. Cell 103 (6) 981-992.
  • González-Gaitán, Marcos; Jäckle, Herbert (2000) Tip cell-derived RTK signaling initiates cell movements in the Drosophila stomatogastric nervous system anlage. EMBO Rep. 1 (4) 343-371.


  • González-Gaitán, Marcos; Jäckle, Herbert (1999) The range of spalt-activating Dpp signalling is reduced in endocytosis-defective Drosophila wing discs. Mech. Dev. 87 (1-2) 143-151.


  • Pearl Forjanic, Julia; Chen, Chao-Kung; Jäckle, Herbert; González-Gaitán, Marcos (1997) Genetic Analysis of Stomatogastric Nervous System Development in Drosophila Using Enhancer Trap Lines. Dev. Biol. 186 139-154.
  • González-Gaitán, Marcos; Jäckle, Herbert (1997) Role of Drosophila α-Adaptin in Presynaptic Vesicle Recycling. Cell 88 (6) 767-776.


  • Schmidt-Ott, Urs; González-Gaitán, Marcos; Technau, Gerhard M. (1995) Analysis of neural elements in head-mutant Drosophila embryos suggests segmental origin of the optic lobes. Roux\'s Arch. Dev. Biol. 205 (1-2) 31-44.
  • González-Gaitán, Marcos; Jäckle, Herbert (1995) Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-mediated signaling which is spatially controlled through wingless. Development 121 (8) 2313-2325.


  • González-Gaitán, Marcos; Rothe, M.; Wimmer, E. A.; Taubert, H.; Jackle, H. (1994) Redundant functions of the genes knirps and knirps-related for the establishment of anterior Drosophila head structures.. Proc. Natl. Acad. Sci. USA 91 (18) 8567-8571.
  • Schmidt-Ott, U.; Gonzalez-Gaitan, Marcos; Jackle, H.; Technau, G. M. (1994) Number, identity, and sequence of the Drosophila head segments as revealed by neural elements and their deletion patterns in mutants. Proc. Natl. Acad. Sci. USA 91 (18) 8363-8367.
  • Rothe, Mike; Wimmer, Ernst A.; Pankratz, Michael J.; González-Gaitán, Marcos; Jäckle, Herbert (1994) Identical transacting factor requirement for knirps and knirps-related gene expression in the anterior but not in the posterior region of the Drosophila embryo. Mech. Dev. 46 (3) 169-181.
  • González-Gaitán, Marcos; Capdevila, María Paz; García-Bellido, Antonio (1994) Cell proliferation patterns in the wing imaginal disc of Drosophila. Mech. Dev. 46 (3) 183-200.
  • Kühnlein, Ronald P.; Frommer, Götz; Friedrich, Markus; González-Gaitán, Marcos; Weber, Alexander; Wagner-Bernholz, Juliane F.; Gehring, Walter J.; Jäckle, Herbert; Schuh, Reinhard (1994) spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo. EMBO J. 13 (1) 168-179.



  • González-Gaitán, Marcos A.; Micol, José-Luis; García-Bellido, Antonio (1990) Developmental Genetic Analysis of Contrabithorax Mutations in Drosophila Melanogaster. Genetics 126 (1) 139-155.