2025 DECEMBER

Hepatobiliary MRI and transporter inhibition in volunteers
Radiology. 2025;31:e251899. Assessing drug-mediated inhibition of liver transporter function with MRI: A first-in-human study. Min T, Tibiletti M, Hockings PD, Galetin A, Gunwhy E, Shalom E, Kenna JG, Melillo N, Parker GJM, Schuetz G, Scotcher D, Waterton JC, Rowe I, Sourbron S. PubMed

Experimental models
Cell Mol Life Sci. 2025;In press. Evaluation of a human 3D multicellular hepatic spheroid model as a platform for studying hepatic transporters. Hartauer M, Ho H, Wan M, Murphy WA, Tiley JB, Fallon JK, Bishop CE, Brouwer KLR. PubMed

Int J Mol Sci. 2025;26:11116. Expression of selected pharmacologically relevant transporters in murine non-parenchymal liver cells compared to hepatocytes. Rönnpagel V, Ullrich A, Joseph C, Tzvetkov MV, Runge D, Grube M. PubMed

J Biochem Mol Toxicol. 2025;39:e70659. Functional and transcriptional disruption of hepatic ABC transporters by environmentally relevant Short-Chain Per- and Polyfluoroalkyl substances (PFAS). Collier GE, Lavado R. PubMed

CPT Pharmacometrics Syst Pharmacol. 2025;In press. Impact of obesity and MASH on zonal hepatocellular statin exposure: Pharmacodynamic insights from a permeability-limited multicompartment liver model. Murphy WA, Sjöstedt N, Mendes MS, Hartauer M, Brouwer KLR, Neuhoff S. PubMed

NTCP and hepatitis
J Mol Cell Biol. 2025;In press. CD46 regulates hepatitis B virus entry by modulating cell-surface NTCP levels through cis-interaction. Miyakawa K, Nakai Y, Kameya T, Nishitsuji H, Watashi K, Takeda M, Seya T, Shimotohno K, Kimura Y, Ryo A. PubMed

Mutat Res. 2025;831:111921. Implications of seven NTCP mutations for receptor stability and hepatitis B virus infectivity: A computational analysis. Kardoudi A, Redouane S, Madihi S, Jackson T, Benani A. PubMed

Cholesterol and hepatocyte transporters
Livers. 2025;5:10.3390/livers5030045. Effects of chronic elevation in plasma membrane cholesterol on the function of human Na(+)/Taurocholate Cotransporting Polypeptide (NTCP) and Organic Cation Transporter 1 (OCT1). Idowu JY, McKimens C, Hagenbuch B. PubMed

SLCO1B1 and statin effectiveness
J Pers Med. 2025;15:511. Retrospective evaluation of the impact of SLCO1B1 variation on statin effectiveness. Ahmed Feldman M, Billman K, Sennoun M, Ng G, Hussain M, Schlosser EG, Hincapie AL, Allen JD. PubMed

Liver fibrosis and transporters
Cell Mol Gastroenterol Hepatol. 2026;20:101630. Loss of bile salt export pump (Bsep/Abcb11) ameliorates toxin-induced hepatic fibrosis via suppression of hepatocellular jun amino-terminal kinase signaling and hepatic stellate cell activation. Fuchs CD, Dixon ED, Königshofer P, Claudel T, Mlitz V, Scharnagl H, Stojakovic T, Reiberger T, Trauner M. PubMed

Review
Antioxidants (Basel). 2025;14:1326. Bilirubin hepatic and intestinal transport and catabolism: Physiology, pathophysiology, and benefits. Kipp ZA, Pauss SN, Martinez GJ, Hinds TD Jr, Lee WH. PubMed