2024 OCTOBER

Drug-drug interactions
Clin Pharmacol Ther. 2024;116:1013-1022. Comprehensive evaluation of OATP- and BCRP-mediated drug-drug interactions of Methotrexate using physiologically-based pharmacokinetic modeling. Hwang S, Lee Y, Jang Y, Cho JY, Yoon S, Chung JY. PubMed

Clin Pharmacol Ther. 2024;116:1334-1342. Coproporphyrin-I as a selective OATP1B biomarker can be used to delineate the mechanisms of complex drug-drug interactions: Cedirogant case study. Kikuchi R, Qian Y, Badawi M, Savaryn JP, Gannu S, Eldred A, Hao S, Salem AH, Liu W, Klein CE, Mohamed MF. PubMed

Cancer Res Commun. 2024;4:2489-2497. Systematic evaluation of tyrosine kinase inhibitors as OATP1B1 substrates using a competitive counterflow screen. Drabison T, Boeckman M, Yang Y, Huang KM, de Bruijn P, Nepal MR, Silvaroli JA, Chowdhury AT, Eisenmann ED, Cheng X, Pabla N, Mathijssen RHJ, Baker SD, Hu S, Sparreboom A, Talebi Z. PubMed

Pharmacol Res Perspect. 2024;12:e70017. Plasma and urinary CP I and CP III concentrations in chimeric mice with human hepatocytes after rifampicin administration. Shishido Y, Yoshida T, Oshida K, Uchida M. PubMed

OAT transporter and organ crosstalk
Pharmacol Ther. 2024;263:108723. Organic anion transporters in remote sensing and organ crosstalk. Granados JC, Nigam SK. PubMed

Hepatic clearance
Drug Metab Dispos. 2024;52:1060-1072. Predicting clearance with simple and permeability-limited physiologically based pharmacokinetic frameworks: Comparison of well-stirred, dispersion, and parallel-tube liver models. Nagar S, Parise R, Korzekwa K. PubMed

Xenobiotica. 2024:1-12. How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data. Schulz Pauly JA, Kalvass JC. PubMed

Drug Metab Dispos. 2024;52:1048-1059. Proof of concept of an all-in-one system for measuring hepatic influx, egress, and metabolic clearance based on the extended clearance concept. Schulz Pauly JA, Sande E, Feng M, Wang YT, Stresser DM, Kalvass JC. PubMed

Transporter expression
Drug Metab Dispos. 2024;52:1152-1160. Differential tissue abundance of membrane-bound drug metabolizing enzymes and transporter proteins by global proteomics. Singh DK, Ahire D, Davydov DR, Prasad B. PubMed

OATP1B1 transport
Drug Metab Dispos. 2024;52:1323-1331. Molecular mechanisms for the selective transport of Dichlorofluorescein by human Organic Anion Transporting Polypeptide 1B1. Liu H, Li L, Liang T, Huan R, Hagenbuch B, Gui C. PubMed

Transporter regulation
Int J Biol Macromol. 2024;278(Pt 2):134748. Human organic anion transporting polypeptide 1B3 (OATP1B3) is more heavily N-glycosylated than OATP1B1 in extracellular loops 2 and 5. Liang T, Liu H, Li L, Huan R, Gui C. PubMed

Bull Exp Biol Med. 2024;177:630-634. Regulation of the Organic Anion Transporting Polypeptide 1B3 (OATP1B3) by sex hormones. Slepnev AA, Abalenikhina YV, Shchulkin AV, Ananyeva PD, Yakusheva EN. PubMed

Transporter and bile flow
J Hepatol. 2024;In press. Hepatocyte aquaporin 8-mediated water transport facilitates bile dilution and prevents gallstone formation in mice. Huo X, Yu Z, Zhao F, Chen Y, Chen P, Xing L, Qiao Y, Peng Y, Tian M, Zhou M, Wu F, Wang Y, Wang C, Tian X, Lv D, Zhang B, Shi L, Ma X, Ma T. PubMed

Food Funct. 2024;15:9916-9927. Arachidonic acid enhances hepatocyte bile acid uptake and alleviates cholestatic liver disease by upregulating OATP1 expression. Ma Y, Zou C, Yang Y, Fang M, Guan Y, Sun J, Gao Y, Shang Z, Zhang X. PubMed