2026 FEBRUARY

Experimental models of DDI
Drug Metab Pharmacokinet. 2026 Jan;67:101517. Quantitative prediction of human pharmacokinetic drug-drug interactions and drug clearance using humanized liver chimeric mice: a review. Miyake T, Tsutsui H. PubMed

Drug Metab Pharmacokinet. 2026;67:101528. Applications of in vitro transporter assays for mechanistic characterization and prediction of clinical drug-drug interactions. Herédi-Szabó K, Ito S, Liang X, Park Y, Parvez M, Sandoval P, Shen H, Staiger KM, Tetsuka K, Warren MS, Zou L, Lai Y. PubMed

Int J Mol Sci. 2026;27:1189. Effects of ritonavir, lopinavir, and alcohol on ABC transporters and secretion of bile acid and bilirubin in senescent hepatocytes.
Chen L, Duran E, Headrick D, Ji C. PubMed

Sci Rep. 2026;16:3380. Expression and function of CYP enzymes and hepatobiliary transporters in an improved long-term sandwich culture hepatocyte model. Pacsuta J, Bárány N, Kiszelák K, Csíkvári O, Mártonné Tóth B, Jemnitz K, Gáborik Z. PubMed

Drug Metab Dispos. 2026;54:100220. Investigating organic cation transporter 1 in drug interactions: New findings from in vitro and in vivo cynomolgus monkey studies. Gilibili RR, Gupta S, Deshpande AA, Tong N, Yu D, Veerapuram R, Subramanyam P, Chitransh S, Muthukumar Y, Ghosh K, Chatterjee S, Vachaspati P, Mariappan TT, Soars MG, Shen H. PubMed

Acta Pharmacol Sin. 2026;In press. Clozapine impaired the hypoglycemic effect of metformin by inhibiting hepatic organic cation transporter 1 (OCT1). Wu WH, Dai YD, Feng WK, Chen HR, Zhu XY, Jiang L, Liu XD, Liu L. PubMed

OATP1B1/3 regulation and structure
Drug Metab Dispos. 2026;54:100246. Post-translational regulation of organic anion transporting polypeptide 1B3 transport function by lysine acetylation and lysine deacetylase 6 inhibition. V, Niyonshuti P, Aditya V, Hays FA, Kayesh R, Soderblom EJ, Xu C, Yue W. PubMed

Drug Metab Dispos. 2026;54:100242. Importance of extracellular disulfide bonds for the surface expression and function of human organic anion transporting polypeptide 1B1. Liang T, Dong Y, Huan R, Chen S, Zhang C, Yang L, Jiang J, Gui C. PubMed

J Biol Chem. 2026;302:111217. A conserved salt bridge network stabilizes the hepatic organic anion transporters OATP1B1 and OATP1B3. Barber D, Naughton F, van Hilten N, Grabe M, Paz A. PubMed

Imaging and transporters
Transl Gastroenterol Hepatol. 2026;11:6. Dual-input dual-compartmental uptake and efflux model based on Gd-EOB-DTPA-enhanced MRI for simultaneously assessing liver function and fibrosis. Guo T, Guo Y, Sun P, Huang C, Jin Z, Hao N, Pu F, Yang F, Li X. PubMed

Clin Transl Sci. 2026 Feb;19:e70484. Pacific blue derivatives of paclitaxel as fluorescent probes of OATP1B-type transporters. Nepal MR, Xu Y, Jin Y, Hu P, Hu X, Rane DS, Andres AE, Ahmed EA, Steiger B, Sparreboom A, Peterson BR, Hu S. PubMed

Modelling in health and disease

CPT Pharmacometrics Syst Pharmacol. 2026;15:e70183. Development of a physiologically based model of bilirubin metabolism in health and disease and its comparison with real-world data. Sayin AZ, Kuepfer L. PubMed

J Clin Pharmacol. 2026;66:e70163. Explaining clinically important variability in response to simvastatin treatment using a PBPK/PD approach. Kang W, Conchon Costa AC, Medeiros JIM, Cicali B, Salgado Junior W, Schmidt S, de Moraes NV. PubMed

Experimental model of MASLD
Front Pharmacol. 2026;16:1664808. Development of an in vitro metabolic dysfunction-associated steatohepatitis model to investigate altered drug metabolizing enzymes, transport proteins, and hepatobiliary disposition. Murphy WA, Kyburz S, Ho H, Loop MS, Fallon JK, Tiley JB, Kralj T, Brouwer KLR. PubMed