2025 JUNE

OATP1B substrates
Drug Metab Dispos. 2025;53(7):100101.Characterization of organic anion transporting polypeptide (OATP)1B1 and OATP1B3 humanized rat as a translational model to study the pharmacokinetics of OATP1B substrate drugs. Li Y, Yabut J, Zhang Z, Fauty S, Houle R, Miller H, Zhang NR, Shin MK, Rosahl TW, Zhou HH, Prasad B, Unadkat JD, Chu X. PubMed

Transporters and cholestasis
Adv Anat Pathol. Molecular advances in cholestatic liver diseases. Memon R, Saxena R. 2025;In press. PubMed

Transporter structure
Proteins. 2025;In press. Role of extracellular histidine residues for the function and pH sensitivity of human organic anion transporting polypeptide 1B3. Han W, Liu H, Liang T, Li L, Huan R, Gui C. PubMed

Efflux transporters and species
Drug Metab Dispos. 2025;53:100083. Species difference in the excretion routes of Ciprofol (HSK3486) in rats and humans: Contribution of hepatic transporters and renal UDP-glucuronosyltransferase enzymes. Zhou Y, Guo Z, Meng J, Kang X, Zhang M, Wang H, Gong H, Zhu Q, Chen X. PubMed

Experimental models
Drug Metab Pharmacokinet. 2025;62:101044. Converting suspension-type human primary hepatocytes to be plateable-type for use as an in vitro pharmacokinetics model. Shahin R, Sakai Y, Shirai K, Hashita T, Matsunaga T, Iwao T. PubMed

Am J Physiol Gastrointest Liver Physiol. 2025;329:G1-G16. A novel human hepatocyte cell line to study PNPLA3-associated steatotic liver disease. Huang G, Wallace DF, Subramaniam VN. PubMed