2025 AUGUST

OATP function
Drug Metab Dispos. 2025;53:100138. Regulation of hepatic organic anion transporting polypeptide 1B-type transport function by the protein kinase LYN. Xu V, Nepal MR, Ahmed E, Kaczynski BD, Xu Y, Gallo JM, Huang KM, Sparreboom A, Hu S, Sprowl JA. PubMed

Drug Metab Dispos. 2025;53:100132. Hepatic uptake of estradiol-3-glucuronide and estradiol-3-sulfate-17beta-glucuronide by human organic anion transporting polypeptides 1B1, 1B3, and 2B1. Li L, Huan R, Liang T, Liu H, Dong Y, Chen S, Zhang C, Gui C. PubMed

Biology (Basel). 2025;14:744. The effect of radixin on the function and expression of organic anion transporting polypeptide 1B1. Ni C, Tang L, Wang X, Li Z, Hong M. PubMed

Transport inhibition of hepatitis B virus and NTCP
Antiviral Res. 2025;243:106267. A novel synthetic bile acid derivative inhibits hepatitis B virus infection at entry step by interfering with the oligomerization of sodium taurocholate co-transporting polypeptide. Rsi Suwardana GN, Abe T, Deng L, Matsui C, Okitsu T, Yamada T, Hatano M, Wiriyasermkul P, Nagamori S, Gad SA, Aly HH, Nishitsuji H, Shimotohno K, Shoji I. PubMed

PBPK modelling
Toxicol Appl Pharmacol. 2025;504:117525. Prediction of human pharmacokinetics of procymidone and its major phase I and II metabolites using a PBPK model with enterohepatic circulation. Hirasawa K, Adachi T, Takeuchi H, Kuroda T, Abe J, Nakajima M. PubMed

OCT1 and hepatotoxicity
Drug Metab Dispos. 2025;53:100134. Organic cation transporter 1 and cytochrome P450s play crucial roles in coptisine- and worenine-induced hepatotoxicity. Zhang H, Luo J, Yi Y, Yuan L, Zhao J, Zhao Y, Zhou H, Yao J, Jiang H. PubMed

Experimental model
bioRxiv. [Preprint]. 2025; 2025.07.11.664464. A 3D in vitro model of the human hepatobiliary junction. Westerfield AD, Grzelak KA, Katsuyama K, Kumar V, Miller BM, Yun J, Kirkpatrick J, Mankus D, Bisher ME, Lytton-Jean AKR, Jiang ZG, Lee DD, Chen CS, Bhatia SN. PubMed

Front Toxicol. 2025;7:1574387. Bioengineering of novel organotypic 3D human liver tissue model for drug-induced liver injury and toxicity studies. Holm C, Finelli J, Frare M, Armento A, Ayehunie S. PubMed

Hepatocyte transporter and pregnancy
Drug Metab Dispos. 2025;53:100118. Regulation of expression and activity of hepatic transporters by pregnancy-related hormones in HepaRG cells. Sharma S, Unadkat JD. PubMed

Sorafenib and hepatocellular carcinoma
Clin Epigenetics. 2025;17:120. Decitabine regulates the resistance of HCC to sorafenib through demethylation. Zhang M, Zhou X, Li Z, Zhao T, Miao Y, Liu S, Han Q, Wang L, Xu Y, Cui T, Wang Z, Yi X, Yan F, Wang X. PubMed

Review article
Hepatology. 2025; In press. Benefits and challenges to therapeutic targeting of bile acid circulation in cholestatic liver disease. Trauner M, Karpen SJ, Dawson PA. PubMed