2024 AUGUST
Sorafenib and hepatocellular carcinoma
Clin Res Hepatol Gastroenterol. 2024;48:102434. Mechanisms of sorafenib resistance in hepatocellular carcinoma. Liang Y. PubMed
Clin Pharmacol Ther. 2024;116:328-345. Risk versus benefit of tyrosine kinase inhibitors for hepatocellular carcinoma: A systematic review and meta-analysis of randomized controlled trials. Payo-Serafín T, Méndez-Blanco C, Fernández-Palanca P, Martínez-Geijo J, Reviejo M, Ortiz-de-Urbina JJ, González-Gallego J, Marin JJG, Mauriz JL, San-Miguel B. PubMed
Experimental model
Cancer Res Commun. 2024;In press. Systematic evaluation of tyrosine kinase inhibitors as OATP1B1 substrates using a competitive counterflow screen. Drabison T, Boeckman M, Yang Y, Huang KM, de Bruijn P, Nepal MR, Silvaroli JA, Chowdhury AT, Eisenmann ED, Cheng X, Pabla N, Mathijssen RHJ, Baker SD, Hu S, Sparreboom A, Talebi Z. PubMed
Drug Metab Dispos. 2024;In press. Utility of chimeric mice with humanized livers for predicting hepatic organic anion transporting polypeptide 1B (OATP1B)-mediated clinical drug-drug interactions. Feng B, Liang G, Zetterberg C, Li S, Huang H, Williams J, Gao H, Morikawa Y, Kumar S. PubMed
Sci Rep. 2024;14:17334. OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids. Mickols E, Meyer A, Handin N, Stüwe M, Eriksson J, Rudfeldt J, Blom K, Fryknäs M, Sellin ME, Lauschke VM, Karlgren M, Artursson P. PubMed
Commun Biol. 2024;7:898. Identification of new correctors for traffic-defective ABCB4 variants by a high-content screening approach. Lakli M, Dumont J, Vauthier V, Charton J, Crespi V, Banet M, Riahi Y, Ben Saad A, Mareux E, Lapalus M, Gonzales E, Jacquemin E, Di Meo F, Deprez B, Leroux F, Falguières T. PubMed
Am J Physiol Gastrointest Liver Physiol. 2024;327:G424-G437. Assessing the degree of hepatic ischemia-reperfusion injury using physiologically based pharmacokinetic modeling of sodium fluorescein disposition in ex vivo machine-perfused livers. Monti CE, Hong SK, Audi SH, Lee W, Joshi A, Terhune SS, Kim J, Dash RK. PubMed
Transporters and pregnancy-related hormones
Front Pharmacol. 2024;In press. The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes. Benzi JRL, Tsang YP, Unadkat JD. PubMed
Transporters and enterohepatic recirculation
Clin Pharmacol Ther. 2024;In press. Developmental expression of drug transporters and conjugating enzymes involved in enterohepatic recycling: Implication for pediatric drug dosing. Thakur A, Subash S, Ahire D, Prasad B. PubMed
Transporters and inflammation
J Pharmacol Exp Ther. 2024;In press. Dysregulation of human hepatic drug transporters by proinflammatory cytokines. Hao T, Tsang YP, Yin M, Mao Q, Unadkat JD. PubMed
Hepatic clearance
Drug Metab Dispos. 2024;In press. Hepatocyte uptake and loss assay (HUpLA): Proof-of-concept of an all-in-one system for measuring hepatic influx, egress, and metabolic clearance based on the extended clearance concept. Schulz Pauly JA, Sande E, Feng M, Wang YT, Stresser DM, Kalvass JC. PubMed
Lipids and transporter function
J Phys Chem Lett. 2024;15:7901-7908 Cholesterol allosterically modulates the structure and dynamics of the taurocholate export pump (ABCB11). Hosamani S, Chakraborty S. PubMed
Biophys J. 2024;123:2522-2536. Coupling the role of lipids to the conformational dynamics of the ABC transporter P-glycoprotein. De Vecchis D, Schäfer LV. PubMed
Atorvastatin and OATP2B1
Drug Metab Dispos. 2024;52:957-965. Impact of OATP2B1 on pharmacokinetics of Atorvastatin investigated in rSlco2b1-Knockout and SLCO2B1-Knockin rats. Kinzi J, Hussner J, Seibert I, Vythilingam M, Vonwyl C, Gherardi C, Detampel P, Schwardt O, Ricklin D, Meyer Zu Schwabedissen HE. PubMed
Substrates of OATP3A1
FEBS J. 2024;In press. Transport of aromatic amino acids l-tryptophan, l-tyrosine, and l-phenylalanine by the organic anion transporting polypeptide (OATP) 3A1. Surrer DB, Schüsser S, König J, Fromm MF, Gessner A. PubMed
DDI and transporters
Clin Pharmacol Ther. New biomarkers for renal transporter-mediated drug-drug interactions: Metabolomic effects of Cimetidine, Probenecid, Verapamil, and Rifampin in humans. Gessner A, König J, Wenisch P, Heinrich MR, Stopfer P, Fromm MF, Müller F. PubMed
Eur J Pharm Sci. 2024;200:106852. Preincubation-dependent inhibition of organic anion transporting polypeptide 2B1. Sinokki A, Miinalainen A, Kiander W, Kidron H. PubMed
Drug Metab Dispos. 2024;52:886-898. Mechanistic account of distinct change in Organic Anion Transporting Polypeptide 1B (OATP1B) substrate pharmacokinetics during OATP1B-mediated drug-drug interactions using physiologically based pharmacokinetic modeling.
Hegde PV, Morse BL. PubMed