2025 OCTOBER

Scientific interest for hepatocyte transporters seems to decline ….

JHEP Rep. 2025;7:101534. NTCP ubiquitination enables HBV infection. Appelman MD, Nguyen TA, Oswald A, Lucko A, Paulusma CC, Protzer U, van de Graaf SFJ. PubMed

Eur J Pharm Sci. 2025;215:107322. Effects of nonsense genetic variants on OATP1B1 expression and transport activity in vitro. Kiander W, Rashidpour H, Gynther M, Vellonen KS, Neuvonen M, Vesalainen L, Huttunen KM, Niemi M, Kidron H. PubMed

Acta Pharmacol Sin. 2025;in press. Species differences in the hepatobiliary disposition of morphine-6-glucuronide mediated by hepatic transporters in rats and humans. Guo ZT, Wang H, Xie NJ, Zhou YF, Zhang ML, Kang XY, Wang J, Zhu Q, Chen XY. PubMed

Mol Pharmacol. 2025;107:100069. Interaction between W41 of the hepatitis B virus preS1 surface peptide and Y146/F274 of the cellular receptor molecule Na(+)/taurocholate co-transporting polypeptide is essential for virus entry. Kunz S, Soppa L, Leidolf R, Neubauer A, Lütteke T, Glebe D, Geyer J. PubMed